Familial amyloid polyneuropathy

Author information: (1)Department of Neurology, Centre Hospitalier Universitaire Henri-Mondor, Cr teil, France. Familial Amyloid Polyneuropathy is caused by an inherited defect in the livers synthesis of transthyretin (TTR a protein which normally transports thyroxin hormone and Vitamin A in the bloodstream. Ionis TTR Rx In patients with familial amyloid polyneuropathy (FAP TTR amyloid deposits cause nerve disease (peripheral and autonomic neuropathy). FAP was first identified as a distinct condition in 195 when it was described in several families in Portugal.

There is a genetic glitch in the formation of transthyretin, which misshapes the protein). The most common type of FAP, caused by the Val30Met variant of TTR, affects about in 5people in some regions of Northern Portugal. TTR-FAP is a disease that affects your nervous causes too much of a protein called amyloid to build up in your bodyaposs.

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Familial Amyloid Polyneuropathy - Causes, Treatment

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